Blake is said to have hailed from Norman Drive in Kingston, Jamaica.
The Trindad and Tobago Police state that they were called to a guest house along Alberto Street, Woodbrook about 11:00 pm on Monday night, where Blake was found bleeding from what appeared to be multiple stab wounds.
Blake was rushed to the Port of Spain General Hospital by the Emergency Health Service.
He succumbed to the injuries and was pronounced dead on Tuesday morning.
The body of Khaliq Blake will undergo an autopsy to determine the cause of death.
The Port-of-Spain Police are investigating.